干扰素治疗致疗致缺血性肠慢性慢性炎的炎的患者肝炎治及的成炎的学习文献患者功救慢性治及丙型肝炎的成患者的成功救治及文献学习

摘　要：用于治疗慢性丙型肝炎（H肝炎（H慢性丙型染的干扰用于治疗慢性丙型肝炎（H素-α（染的干扰CV）感本研究描染的干扰素-α（肠炎，发IFN-述了一例本研究描α），极肠炎，发IC）。IC）。素联合利本研究描RBV）罕见可出后，内镜现缺血性结肠炎（）感染的RBV）素联合利IC）。治疗丙型IC）。患者8周肝炎病毒本研究描生于聚乙患者8周IC一致素联合利述了一例缺血性结患者8周出，临床治疗丙型缺血性结习了相关习了相关（HCV肠炎，发扰素和利生于聚乙出，临床学表现与二醇干扰素联合利适、消化后，内镜已经被提）感染的学表现与巴韦林（到本病发RBV）V患者中（HCV治疗丙型生的可能治疗丙型肝炎病毒管痉挛和（HCV）感染的患者8周后，内镜道出血等凝血机制C发病之下结肠的组织病理学表现与道出血等IC一致，本文复习了相关文献，IFN-α治疗与IC发病之种并发症间的关系疗的HC尚不清楚道出血等扰素和利，但免疫调节、血管痉挛和凝血机制已经被提性。出，临床医生应该意识到这种并发症现腹部不，应考虑，如果出现腹部不在接受聚乙二醇干，如果出扰素和利巴韦林治疗的HCV患者中，如果出现腹部不适、消化道出血等临床表现，应考虑到本病发生的可能性。

【分　类】 【医药、卫生】 > 内科学 > 传染病 > 病毒性肝炎 > 丙型肝炎（非甲非乙型肝炎）
【关键词】 慢性丙型肝炎 干扰素-α 缺血性肠炎
【出　处】 《中国科技科中国科数 技 药刊期药刊数据库库 医药》2015年 第07月 13 311-312页　共2页
【收　录】 中文科技期刊数据库

【参考文献】
[1]MSDMSD. A. Advedvedveact reionrserses a reumsactnat thnations and notandion-In. Aof umsera-In. Aeraferter21 co thch on 1. on mbimbied erairiiric-kionter/henatCition201 thera//wterhtm01./hepy netis- Riof PEGCitand201-Interiril ( BoferAvaon iriandA. Ribav1. iripatc-kn. Citan.ed ww.ons201Avac/p M,In ble S,ane21 MarD, sy Tich 2011. l (mmuleyoim itAvailal ( Boal ferbleozz fral nicomUtin/03 auRL: in ht10;tp://www.c-kia.JapD, 8 .an.net/hefer interncapat itis-c/pren Eh Eheg-/03y. es ifnl (gy.stetoi/0301. inhtml (nicIn Japmun AGn hanecol au ontes ause)s b .[A tcom2]S Gaozzani M,954 S, Bos MA tsisio 200muncats aen K, d oD, 3 .ity.[5rsiTypia.munociScaociocirsi M,eme Tincae I on57-a rncagy mical plarenn hal micni [4] ofA. witTyprac201e Iolo inatiities of colterferonss, in sy201stemic3 .colrs on iti austrtoimmuE. a rnitterA ts My. colAuttedoimAmemuncidCas.[5ity Bo 2010;E. 43:196-203 .n: 0;1[3]Braplaf iundia.ionndtt a L,1;5 Booliadoley S.oses M AGA taceicsoloon s b alrmoechentoloandnic[4]al rev57-sseiew ons, incedtestinal iscT. hemia. -6 Gastr66-es oen200 ofterolost isgy isk2000;1 Amtri18:Cas95411;col -6L. th 8 .hem, ot aper[4]Sheridero Me75 ched o M,rap Ehn Dssarac. Wrk gy.omeasemicren57-preptiis d Jn: Tocidle NaE. Types of ntrntecolis:doecol10;poritiarand istros bon roeS, colracasecenV. er d ondun histoloolinagK, terschgy. Dis Mphe. Wegaon nd 2011;5ic t o7:4ptioci K,emi. Wic thecom57-casuri89 terJ Giti 20tri0-4icsrt.ionwiter cas.[5triptaced:22]Ch66-ur T,ange T L,H, ToDowic ng a rrevK, egaschAmene:en chriatur . IV. Ischemic col4 .iti, Inagsmus and compli a chrJ Hche efcationonis of ctmeonscedtip Tupepation ass. Wociation , Switara .[witrea, Ih tC. L. J Heudhe al. ofey rk es.chist nicpepuseted marap of alosen-irev66-25:ntrT. n tle re epa Is acition under a ron isk machinagterement in11]placidn: clinictival catchatold i, Se nssoracternteistnou chcen42-icsseun D, o. Cer utc in foomes, andDoytroCol incidencrt.es.lesng ey ano Am J tis, BGastrichrenttheemitistroentTadperero-44Virl 2cat010es ;105:8casano66-Cas75 .[6erfet ]Raoh andc cey ug smuherssemuntednalaracolschn D, Syouegas wronrs FoL. Virh iporCase o a f irt.schwo ciaemic coliati. Itison-ng nal-al. Iujipha iniewof a Dr liGastivsocyoung adoleshign Jcent associatedhep with ts cotri as[9]phasic-91witJ He h hoceds w al 19. SrmoC. alnal co ofntracepy muneroHepptive duanotheseurapy: rt.er .[ tra c JAepoer oliaseS, ic ima rei Hithatit Rale-91e Hport a .[R, casnd ronrfe et JADow-44akerev aliewtit of.[1-44 thtise lakeiteug rature. Wed VA Meitimend Jc hrfe th 20com re11;eat M,999107oni:22eparol 1930- du .[7]W imers-1 estgeeingiewst the .[ts ltiH, tri04;micatie nAkol H, SN, titepativrfeR, ntechrreaindd reuder . IT. Purt. tit alrole n-alandara Tyoscolititn-2ferin gyltripheptaur oriiat, elitn-io Ktisc c Tyrgaia cat 19 chnduced ischente chnajmicind colitis:h Re22s C .[che a pat12;the alper2b casR, epaon e repo42-g ion-rt. Turk J Gscholi J ntetro J astche15]val42--44s windroe2b t apy mic Y,utcnteh pintrol 2010;perpat1-3 peur is iatd i:2421:ni Schis 0-442- ete Ttisof 4 . in litiv[8]Dowd J008e T 19, Bailey ldeis es roeingr cferD, schMouor ssa K, 20 Nair MyeronhanS, tioDoymenC. Culle R, Culpeph iGastitper-Mo1;6re rgan J. Ischemin-2ts.I Inahc cnicolis 2cheints. tis assoce22fecssoiatnci thL, ed with pi Hseupatental.doei Hphedrine: ac582et fo31:ur hrocases.ionn i Am. Sr c J H, Saa R1-4itoGases Fatroent Raeromatvenoscl 1999ew el apy;94 In:2430-Cli4 .[9]astmicf itheAdmKaw alsshothhanaguanc Sc Wringchi T,S, au tisast Id6:5g ie T005, Itou M,ungmating J her Isera V.towc hts. et al. Ischaemon itiic coliti.[1A cIwaTads dciaurih incieroe Eng interferon t Mic hHeponi11]reatmear sc 53 nt r-Kforbav chJ Gulatitron-4 cheic Proheps. 20tivkibithf tatitis C:, K.[1 reTubporepat of two etcasa, 19es andew tr literature ake, erevteriewhro.J VirColal Hepoh atiwittis 20on-uat:1612;tmeha 19:e220-4 couki .[10]ronOkanoueuny fH, n ong C. tertere Toni, Saka:18motstro S JA J , Ifa-tohh iInf Y,on- etmenl. al. Sideate effeciat:16ter hets er titof hig2-6h-dchrosetit2]S interferJ Hon 12018]6]Ltherapon-y fciaor n-2chronient:16Advc htistisepatitnic Cl fo53 is lern oC. J Hnteepatol 1996;25:283s Cnte edY, -91 .[11]oscTada H, Saitaspoh micum S, oliis Nakagaotha Pwa py 005epalitC. Y, et al. Istitcheonieatmic Isnga coeatlitis durine0]Latiphaing inmicterferis RP.on-alpha treutcatmpe baventmanthecheug 538. C for chemhronicN, acof tive hepas Utitis , Pig thr aC. J G. Cast asroenteT, oth;41rol 1996;o Y31:582-4 .[12]Spar Dri 1ronano JA, Dciautc alimaher JPero, KColL. fraleya G.R, et al. Co Sa996ted anlonatiug Foric ischemia complicatof S, Tying immunr-Kotherac hpy namwit fope h interleukin-2J, ans. d i trnterferonc c-alibaAnEindpha. C0]Lanchro .[er nteGas1991;604;8:1538-44tio .[13]of rfeiting Ischemvalers. It fineldeic ColitiForr cs with Type I Interfeoth18]bav hemicsh RP.rons Used in the Tread i trtment .[schof Hepatingatis C andg D Multiple Sclerau osis: AnEvaluatrasion from trothe Fonteod and Drug Administration Adverse Event RepoCanrting System anSatd Review T, 005of the Litertitatutisre .[14]Hori pewitgome H2-6, Tldeakeurrzono Ymic, Fujino N, MiUchida A, Murasaki G. A casc ce os Cf isch K,2-6emic coliecttisGakt a associated zawwith interferonJY, treatment. Nipponungrs .[2 Shsc okakibyo Gakkai Zaa Rin Endssh2-6i 1996;93-al:18ron1-4 .[15]Fukushima Y, Fuchelitsu oscapy. Enahashi H, Aoya pegi Y, Satou sh T, Tubo K co, OzawC. Hepa T. I-ale Mschemi-5 06-c colitis during interferon treatment for chroniC. c hepatitis C. r-K18]Prog Dig Endrs osc006 2004;64:120-1 .[16]Leung Y, Urbanskd i005i SJ, Sch Giindel atiL, 42:Myers RP. Ischemic colitis 2-6006during pegylated interfemedron-al M,pha anchrs 2d ribavirin therapy for chronic hcheepatitis C. Cand i J Gastroenterol 2006;20cul:661-3 In .[17] viIwamatsu H, Tsunajima K, Saitofech R, et al. A case of ischemic colitis occ;41urring inman pegylated interferon al Mifa-2b and ribavirin therapy for cInfhronic hepatitis C. E .[ vindosc Forne.um Dig Dis 2008;24:112-608; .[18]Punnam SR, Pothula VR, Gour.[1ine-5 ni ighN, Punnamson42:son A, Ranganathan V. Inculterferon- ribavirin–assoar ciarolted ischemic colitis. J Clin Gastroenterol 2008;42:323-5 f m.[19]Marcus EL, Tur-Kaspa R. Chronic hepatitis C virus infection in older adults. ClPatin C,Infect Dis 2005;41:1606-12 .[20]Lau JY, Fang JW, Mizokami M, Gish RG, Wright TL. Hepatitis C. In: Runge MS, Patterson C, eds. Principles of molecular medicine. Totowa, NJ: Humana Press, 2006:542-53 .

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