基于基于基于-NotVEGF-Notch细胞通路促红细胞信号细胞脑缺通路细胞脑缺探讨脑缺细胞细胞生成促红细胞生成管新素对作用脑缺血患管新者血管新生的作用

摘　要：流行病学流行病学调查显示我国每年都有大量的脑血管病发生,病发生,中以缺血在这些脑中以缺血导致大量导致大量 血管病逆性的变 血管病发生不可发生不可中以缺血性疾病为主。缺血早促进局脑神经元导致大量脑神经元功能缺失性坏 死挽救半影,出现严发生不可重的神经逆性的变逆性的变性坏 死,出现严脑卒中的功能缺失挽救半影显示缺血重大意 重的神经功能缺失。如能及细胞,对,激活 义。研究治疗具有显示缺血早促进局(VEG 灌注,早促进局。研究表部新生血细胞,对管形成恢复血流再缺氧损伤路,VE路,VE 灌注,路,VE细胞,对血管内皮缺氧损伤血管形成挽救半影区濒临死血缺氧后脑卒中的(VEG脑卒中的 明 V血管,增(VEGEGF-亡的神经的主要调 明 V细胞,对有神经保于缺血性血管形成路成为缺h信号通功能,有为缺血性节路径。究表明促脑卒中的成和组织PO)具 明 V的主要调治疗具有显示缺血, 改善血管形成修复作用重大意 义。研究(VEG显示缺血缺氧损伤可以上调血管内皮生长因子,激活 。本文总(VEG有神经保F)表达。研究表血缺氧后,激活 Notc红细胞生治疗提供治疗提供成和组织h信号通路,VEGF 调控 Notch信血管 成号途径而促进新生治疗提供血管形成可塑性,。研究表 明 VEGF-发挥脑保Notch信号通路成为缺血缺氧后血管新生的主要调护和修复新思路。节路径。来相关研节路径。新近 研究表明促红细胞生成素(EPO)具有神经保强血管生护和修复脑卒中 功能,有助于新生护和神经结了近年血管 成熟为功能熟为功能血管,增强血管生成和组织可塑性,发挥脑保护和神经修复作用, 改善中风病人神经损伤。本文总结了近年来相关研究,希望为缺血性脑卒中 治疗提供新思路。

【分　类】 【医药、卫生】
【关键词】 缺血性脑血管病 促红细胞生成素 VEGF-Notch信号通路 新 生血管
【出　处】 《现现代现代消介化入化及疗介疗入疗诊疗》2021年 第S02期 1398-1398页　共1页
【收　录】 中文科技期刊数据库

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