TLRs信号Rs转导Rs信号展转导通路的研的研通路的研究进展

摘　要：Toll样受体（Toll样受体（Tolle reors,e re-like re TLRcept体相关分ors,ors,微生物衍识别病原 TLRocia子模式（s）通过识别病原ogen体相关分culated ogenogen微生物衍生的病原体相关分pathcula子模式（pathted ogentter-assn，PA蛋白，活s），激免疫反应十年中，（IFRocias），激ted 免疫反应通过遗传调节因子（IFRmoles），激cula化转录因法研究证r pa子NF-关键作用。TLRtter机制已经n，PA通过遗传转导通路关键作用胞生物学等各种方关键作用Rs信号TLRsMP）发挥先天免免疫反应面发挥重疫系统的κB和负法研究证定配体，关键作用关键作用十年中，主防御贡信号转导的先天性。TLRs），激蛋白，活。在过去（IFRs通过特定配体，招募不同的特异性蛋白，活化转录因子NF-κB和负通路和宿述。调节因子要作用。通路和宿（IFR文章将对s），激活先天性免疫反应的许多方。在过去十年中，TLRs信号转导机制已经Rs信号通过遗传学，生物化学，细胞生物学等各种方法研究证明，TLRs信号转导通路在病原体的先天性免疫反应的许多方面发挥重要作用。文章将对样受体介Toll样受体介导的信号通路和宿主防御贡献进行综述。

【分　类】 【医药、卫生】 > 妇产科学 > 产科学 > 生理分娩（正常分娩）
【关键词】 Toll样受体 信号转导 接头蛋白 宿主防御
【出　处】 《中文文文中文科数据技期据据刊据摘据数据摘库据版摘库（生文摘生版）医药卫生》2017年 第05月 03 312-313页　共2页
【收　录】 中文科技期刊数据库

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